Matthew J. Campen

Micro- and nanoplastics alter electrophysiological brain patterns and reshape human neurodevelopmental trajectories

This study shows that micro- and nanoplastics disrupt human brain development and function by inducing inflammation, cellular senescence, and altered electrophysiological activity.

Induction of ferroptotic and amyloidogenic signatures linked to Alzheimers disease by chemically distinct air pollutants

This study shows that metal-rich air pollutants induce ferroptosis and amyloidogenic pathways linked to Alzheimer's disease through shared transcriptional and oxidative mechanisms.

Dietary Microplastics Engage Gut Mechanosensory-Endocrine Signaling and Disrupt Bone Homeostasis

This study shows that dietary microplastics alter gut neuroendocrine signaling and disrupt bone health in mice, with effects dependent on sex and diet.

Nano- and microplastics in pediatric tonsil tissue: bioaccumulation, distribution, and immunomodulatory effects in human lymphoid aggregate organoids

This study characterizes nano- and microplastics in pediatric tonsils and shows they trigger transient immunomodulatory responses in lymphoid organoids.

Photoaged microplastics disrupt endothelial stretch-sensitive ion channels to impair calcium signaling and vascular integrity

This study shows photoaged microplastics impair endothelial calcium signaling and vascular integrity by disrupting Piezo1-Notch mechanotransduction.

Deposition of microplastics associated with bioaccumulation of heavy metals in human lungs of smokers: Implications of adsorption and mobilization of metals via microplastics

This study finds that smoking increases microplastic (MNP) and cadmium (Cd) levels in lung tissues, with a strong correlation between PE microplastics and Cd accumulation.

In vivo exposure of mixed microplastic particles in mice and its impacts on the murine gut microbiome and metabolome

This study shows that microplastic exposure alters gut microbiome composition and serum metabolome in mice, with sex-specific and dose-dependent effects.

Chronic Cadmium Exposures and Hyperglycemia Additively Drive Mitochondrial Dysfunction in Hepatic Cells: Key Implications for MASLD Etiopathogenesis

This study shows chronic cadmium exposure combined with hyperglycemia worsens mitochondrial dysfunction in liver cells, suggesting a role in MASLD development.

Plasma Membrane Damage by Environmental Materials Enhances Cell-Cell Fusion and Impairs Immune Functions of Macrophages

This study shows that environmental materials damage macrophage plasma membranes, reducing ROS and phagocytosis while increasing cell fusion and impairing immune responses.

White matter hyperintensities and microplastics

The paper investigates the presence of microplastics in brain regions with white matter hyperintensities using post-mortem MRI, histopathology, and pyrGC/MS, suggesting a potential link between microplastics and vascular injury in cognitive impairment.