James C. Dodge

The paper shows human iPSC-derived neurons and glia differ in ceramide synthesis, composition, and toxicity sensitivity, linking these differences to inflammation, ER stress, and apoptosis.

This paper introduces a new drug-like small molecule series targeting PDI in a multi-protein complex for ALS treatment, showing activity in cellular and animal models.

The paper identifies novel pathways that enhance oligodendrocyte maturation and myelination through high-throughput screening of 2500 compounds using engineered human stem cell-derived OPCs.

The paper shows microglia are susceptible to ferroptosis in neurodegenerative diseases and identifies SEC24B and small molecules that regulate this process.