Author

Matthew Dowling

Pfizer (United States)ORCID 0000-0002-5140-764XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Aiping DongiD· 1 shared Aliakbar Khalili Yazdi· 1 shared C.H. ArrowsmithiD· 1 shared Caroline Schild‐PoulteriD· 1 shared Chakrapani SubramanyamiD· 1 shared Cong DongiD· 1 shared Dafydd R. OweniD· 1 shared Dalia Baršytė-LovejoyiD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperMolecular Biology

Aiping DongORCID

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1 paper

Recent·Most cited

A chemical probe to modulate human GID4 Pro/N-degron interactions

Dominic D. G. Owens, Matthew E. R. Maitland, Aliakbar Khalili Yazdi, Xiaosheng Song, Viviane Reber, Martin P. Schwalm, Raquel A. C. Machado, Nicolas Bauer, Xu Wang, Magdalena M. Szewczyk, Cong Dong, Aiping Dong, P. Loppnau, Matthew F. Calabrese, Matthew Dowling, , C.H. Arrowsmith

The paper introduces PFI-7, a chemical probe that inhibits GID4 Pro/N-degron interactions, revealing non-degradative roles of the CTLH complex in human cells.

Nature Chemical Biology · May 21, 2024Peer-reviewedMolecular Biology