Author

Matthew F. Calabrese

Pfizer (United States)ORCID 0000-0002-9394-3686Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

Aiping DongiD· 1 shared Aliakbar Khalili Yazdi· 1 shared Alpay Dermenci· 1 shared Andrew C. FlickiD· 1 shared Atli ThorarenseniD· 1 shared Barbara J. HoganiD· 1 shared Brian S. GerstenbergeriD· 1 shared C.H. ArrowsmithiD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperMolecular Biology

Aiping DongORCID

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2 papers

Recent·Most cited

Structural basis for CCR6 modulation by allosteric antagonists

David Jon Wasilko, Brian S. Gerstenberger, Kathleen A. Farley, Wěi Li, Jennifer Alley, Mark E. Schnute, Ray J. Unwalla, Jorge Victorino, Kimberly K. Crouse, Ru Ding, Parag V. Sahasrabudhe, Fabien Vincent, Richard K. Frisbie, Alpay Dermenci, Andrew C. Flick, , Huixian Wu

This paper presents two inactive CCR6 structures bound to allosteric antagonists, revealing structural insights into CCR6 inhibition and its implications for drug discovery.

Nature Communications · Aug 31, 2024Peer-reviewedBiochemistry

A chemical probe to modulate human GID4 Pro/N-degron interactions

Dominic D. G. Owens, Matthew E. R. Maitland, Aliakbar Khalili Yazdi, Xiaosheng Song, Viviane Reber, Martin P. Schwalm, Raquel A. C. Machado, Nicolas Bauer, Xu Wang, Magdalena M. Szewczyk, Cong Dong, Aiping Dong, P. Loppnau, Matthew F. Calabrese, Matthew Dowling, , C.H. Arrowsmith

The paper introduces PFI-7, a chemical probe that inhibits GID4 Pro/N-degron interactions, revealing non-degradative roles of the CTLH complex in human cells.

Nature Chemical Biology · May 21, 2024Peer-reviewedMolecular Biology