Santosh Kesari

Pharmacologic inhibition of OLIG2 by CT-179 disrupts mitotic progression and enhances standard-of-care chemoradiotherapy in glioblastoma

This study shows that CT-179, an OLIG2 inhibitor, reduces glioblastoma growth and enhances chemoradiotherapy efficacy in preclinical models.

Drug and single-cell gene expression integration identifies sensitive and resistant glioblastoma cell populations

The paper integrates single-cell RNA sequencing data with drug response signatures to identify drug-sensitive and resistant glioblastoma cell states and predict synergistic drug combinations.

3D Brain Vascular Niche Model Captures Invasive Behavior and Gene Signatures of Glioblastoma

This paper develops a 3D brain vascular niche model to study GBM invasion and gene signatures, revealing glia-vascular contact influences transcriptional adaptation and poor prognosis.

Plexin-B2 is a key regulator of cell mechanics during multicellular organization

This study identifies Plexin-B2 as a regulator of cell mechanics during multicellular organization, showing its role in modulating cell stiffness, contractility, and differentiation in human stem and progenitor cells.

Disease mechanism, drug-target and biomarker prediction software: Application on prostate cancer and validation

The paper introduces an R software package for differential network analysis to predict disease mechanisms, drug targets, and biomarkers using gene expression data from two conditions, validated on prostate cancer datasets.