Nermin Sumru Bayin

This study shows adult Nestin+ cerebellar astroglia have limited regenerative potential compared to neonatal cells, with ATAC-seq revealing developmental gene silencing as a key factor.

This study shows that reactive oxygen species (ROS) increase in the neonatal cerebellum after injury, and reducing ROS impairs regenerative processes.

The paper identifies FOXO1 as a key regulator of inhibitory neuron differentiation in mouse and human cerebellar progenitors, showing its conservation and regulation by WNT signaling.

The paper identifies molecular subdomains in the medial excitatory cerebellar nucleus (eCNm) and shows that En1/2 mutations disrupt their development and survival.

This paper introduces a fiberoptic probe for hemodynamic spectroscopy in freely-moving mice, showing cerebrovascular dysregulation in Alzheimer's and glioma models.

The paper identifies a transitory cell state driven by ASCL1 that enables neural reprogramming in the injured neonatal brain.

The paper uses scRNA-seq and SCOPE-seq to study adult neurogenesis, identifying NOTUM as a key regulator of V-SVZ NSC differentiation and neurogenesis.

The paper describes the development of genetic mouse lines and tools for inducible and reversible intersectional misexpression of genes with high spatiotemporal control.

The paper investigates how H3K27M mutations inhibit PRC2 in DIPG, revealing mechanisms of chromatin alteration and PRC2 dysfunction.

The paper shows that dormant progenitors regenerate Purkinje neurons after injury, but regenerative capacity declines with age.