Roland H. Friedel

Bone Morphogenetic Protein Pathway Modulates Parkinson's Disease Genetic Risk and Promotes Motor Recovery

The paper investigates the role of the BMP pathway in Parkinson's disease using genetic and pharmacological approaches, finding it contributes to polygenic risk and has therapeutic potential.

Guidance receptor-mediated mechanocompliance of GBM cells facilitates immune-silent invasion

This study identifies how GBM cells use Plexin-D1 and Plexin-B2 to gain mechanocompliance, enabling immune-silent invasion through tissue.

Cortical tension as a mechanical barrier to safeguard against premature differentiation during neurogenesis

This study identifies cortical tension as a mechanical barrier that prevents premature neuronal differentiation during neurogenesis, showing that reducing it accelerates neuronal lineage commitment and differentiation.

3D Brain Vascular Niche Model Captures Invasive Behavior and Gene Signatures of Glioblastoma

This paper develops a 3D brain vascular niche model to study GBM invasion and gene signatures, revealing glia-vascular contact influences transcriptional adaptation and poor prognosis.

A systems approach uncovers drivers of the multifocal emergence of an astrocyte state contributing to cognitive decline in Alzheimer's disease

The paper identifies a novel astrocyte state linked to cognitive decline in Alzheimer's disease and validates its regulators through multi-modal analysis and mechanistic experiments.

AhR restricts axon regeneration by balancing neuronal stress and growth response after injury

This study identifies AhR as a regulator of axon regeneration by balancing stress and growth responses after injury, showing that its inhibition promotes regeneration in nerve and spinal cord injury models.

Plexin-B2 is a key regulator of cell mechanics during multicellular organization

This study identifies Plexin-B2 as a regulator of cell mechanics during multicellular organization, showing its role in modulating cell stiffness, contractility, and differentiation in human stem and progenitor cells.

A resource of targeted mutant mouse lines for 5,061 genes

The paper reports the generation of over 5,000 new mouse mutant strains for targeted genes, significantly expanding the available genetic resources for biomedical research.