The paper uses electron microscopy to compare stem-like and differentiated states in Hydra epithelial cells, revealing distinct ultrastructural features that challenge the traditional separation of stem and differentiated cells.

bioRxiv · Jul 23, 2026 · PreprintEvolutionary Biology

Sephin1 rewires proteostasis through actin-dependent signaling

Giulia Frapporti, Antonella Capuozzo, Eleonora Colombo, Paolo Fioretti, Vincenzo Maria D’Amore, Francesco Saverio Di Leva, Adriano Lama, Vasvi Tripathi, Stefano Medaglia, Stephanie Waich, Caterina Montani, Maria Dolores Perez-Carrion, Antonella Marte, Franco Onofri, Christian Johannes Gloeckner, , Giovanni Piccoli

This study identifies sephin1's mechanism of action in proteostasis disruption by showing it binds G-actin, causes cytoskeleton misfolding, and modulates autophagy through mTORC1-TFEB and GCN2-eIF2-CHOP pathways.

bioRxiv · Jun 3, 2026 · PreprintCell Biology

Molecular dynamics of the matrisome across sea anemone life history

Bruno Gideon Bergheim, Alison G. Cole, Mandy Rettel, Frank Stein, Stefan Redl, Michael W. Hess, Aissam Ikmi, Suat Özbek

The paper identifies conserved matrisomal networks in sea anemones that coordinate life history transitions through proteomic and transcriptomic analysis.

eLife · Oct 23, 2025Peer-reviewedDevelopmental Biology