Pedro Escoll

This study uses single-cell metabolomics to show that Legionella pneumophila infection induces metabolic reprogramming in human macrophages, with bacterial effectors promoting glycolytic shifts.

This study identifies MYC and MAX as critical for post-mitotic genome reactivation in pluripotent mouse embryonic stem cells, showing MAX's role in bookmarking and MYC recruitment.

This study shows Salmonella can replicate in macrophages without Type III Secretion Systems if provided with preferred nutrients, highlighting the role of host metabolic heterogeneity in bacterial replication.

This study identifies RidL as a bifunctional effector that inhibits retrograde trafficking and promotes mitochondrial fragmentation by phosphorylating Drp1, aiding Legionella pneumophila's intracellular survival.

This study identifies Complex I as essential for maintaining mitochondrial membrane potential during infection with virulent bacteria, revealing distinct strategies used by Legionella and Salmonella.

The paper tracks metabolic dynamics in single human macrophages infected with Legionella pneumophila to predict bacterial replication with 83% accuracy using machine learning.

The paper presents chromosome-scale genome assemblies of Acanthamoeba castellanii and shows infection-induced chromatin reorganization during Legionella pneumophila infection.