Author

Myriam A. Armant

Boston Children's HospitalORCID 0000-0002-5205-3003Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:perturbation response prediction· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Daniel E. BaueriD· 2 shared Jing ZengiD· 2 shared Linda Yingqi LiniD· 2 shared Luca PinelloiD· 2 shared Marioara-Felicia Ciuculescu· 2 shared My Anh Nguyen· 2 shared Scot A. WolfeiD· 2 shared Stacy A. Maitland· 2 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenetics

Daniel E. BauerORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells

Jing Zeng, My Anh Nguyen, Pengpeng Liu, Lucas Ferreira da Silva, Sébastien Levesque, Linda Yingqi Lin, David G. Justus, Karl Petri, Kendell Clement, Shaina N. Porter, Archana Verma, Nola R. Neri, Tolulope O. Rosanwo, Marioara-Felicia Ciuculescu, Daniela Abriss, , Daniel E. Bauer

This study shows that gene editing of HSCs without ex vivo culture reduces genotoxicity while maintaining therapeutic efficacy for beta-hemoglobinopathy treatment.

Cell stem cell · Dec 12, 2024Peer-reviewedGenetics

Human genetic diversity modifies therapeutic gene editing off-target potential

Samuele Cancellieri, Jing Zeng, Linda Yingqi Lin, Manuel Tognon, My Anh Nguyen, Jiecong Lin, Nicola Bombieri, Stacy A. Maitland, Marioara-Felicia Ciuculescu, Varun Katta, Shengdar Q. Tsai, Myriam A. Armant, Scot A. Wolfe, Rosalba Giugno, Daniel E. Bauer, Luca Pinello

The paper develops CRISPRme, a tool that integrates genetic diversity data to assess off-target risks of gene editing, finding allele-specific off-target effects in clinical gRNAs.

Nature Genetics · Dec 15, 2022Peer-reviewedGenetics