Author

Lucas Ferreira da Silva

Broad InstituteORCID 0000-0002-7744-4369Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:benchmarking· 2 Approach:experimental assay· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Research Focus:perturbation response prediction· 1 Research Focus:software / tool· 1 Approach:statistical model· 1

Frequent Co-Authors

Archana Verma· 2 shared Christian BrendeliD· 2 shared Daniel E. BaueriD· 2 shared Danilo PelliniD· 2 shared Jing ZengiD· 2 shared Kendell ClementiD· 2 shared Linda Yingqi LiniD· 2 shared Luca PinelloiD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenetics

Archana Verma

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Pre-clinical studies of Schistosoma mansoni vaccines: a scoping review

Emma L. Houlder, Lucas Ferreira da Silva, Angela van Diepen, Murilo Sena Amaral, Robert Alan Wilson, Cornelis Hendrik Hokke, Meta Roestenberg, Wilfried A.M. Bakker

This paper reviews pre-clinical Schistosoma mansoni vaccine studies, finding that only two antigens achieved over 90% efficacy, but most vaccines fall short of required thresholds due to variable formulations and study designs.

PLoS neglected tropical diseases · Jun 2, 2025Peer-reviewedImmunology

Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells

Jing Zeng, My Anh Nguyen, Pengpeng Liu, Lucas Ferreira da Silva, Sébastien Levesque, Linda Yingqi Lin, David G. Justus, Karl Petri, Kendell Clement, Shaina N. Porter, Archana Verma, Nola R. Neri, Tolulope O. Rosanwo, Marioara-Felicia Ciuculescu, Daniela Abriss, , Daniel E. Bauer

This study shows that gene editing of HSCs without ex vivo culture reduces genotoxicity while maintaining therapeutic efficacy for beta-hemoglobinopathy treatment.

Cell stem cell · Dec 12, 2024Peer-reviewedGenetics

Scalable assessment of genome editing off-targets associated with genetic variants

Jiecong Lin, My Anh Nguyen, Linda Yingqi Lin, Jing Zeng, Archana Verma, Nola R. Neri, Lucas Ferreira da Silva, Adele Mucci, Scot A. Wolfe, Kit L. Shaw, Kendell Clement, Christian Brendel, Luca Pinello, Danilo Pellin, Daniel E. Bauer

The paper develops ABSOLVE-seq to assess genome editing off-targets linked to genetic variants using primary cells and sequencing, enabling evaluation of human genetic diversity's impact on gene editing specificity.

bioRxiv · Jul 24, 2024 · PreprintGenomics