Daniel O’Connor

Genome-wide association study of susceptibility to pneumococcal carriage amongst children

This study identifies genetic loci associated with pneumococcal carriage in children through a genome-wide association analysis.

Typhoid toxin of Salmonella Typhi elicits host antimicrobial response during acute typhoid fever

This study shows that typhoid toxin from Salmonella Typhi triggers DNA damage responses, leading to antimicrobial effects like lysozyme secretion that inhibit bacterial virulence.

Hypoxia-related immune subsets induced by Salmonella Typhi infection link early bacterial gut invasion to human infection outcomes

This study links hypoxia-related immune subsets in human and mouse models of Salmonella Typhi infection to disease outcomes.

Effects of technical noise on bulk RNA-seq differential gene expression inference

The paper investigates how technical noise affects bulk RNA-seq differential gene expression analysis and proposes noise-adjustment methods to improve consistency across tools.

Elevated risk of invasive group A streptococcal disease and host genetic variation in the human leukocyte antigen locus

The paper identifies an association between the HLA-DQA1*01:03 allele and increased risk of invasive group A streptococcal disease using case-control studies and HLA imputation.