Siyuan Ding

This study shows that rotavirus NSP1 activates the NLRP1 inflammasome through proteasomal degradation, independent of double-stranded RNA.

The paper shows neutrophils store and release IFN-I from the nucleolus, revealing a new role for nucleolar stress in immune responses.

This study identifies how the coronavirus envelope protein disrupts the TAp73-FDXR axis to cause iron overload, leading to iron deficiency perception and tissue damage, and presents a therapeutic molecule to counteract this effect.

This study identifies the signal peptidase complex (SPC) as essential for rotavirus VP7 processing and virion assembly, showing that SPC cleavage of VP7's signal peptide is critical for infectious particle formation.

This study identifies FcRn and DPP4 as human astrovirus receptors and shows that targeting these factors with existing inhibitors prevents infection in human enteroid cultures.