James C. Smith

This study identifies lonafarnib as a potential therapy for progeria-related cardiac senescence by activating autophagy and reducing progerin expression in human and mouse models.

The paper identifies epigenetic marks specifying human DNA replication origins through oxidation of 5-methyl-deoxycytidine by TET enzymes.

This study generates fam83f knock-out zebrafish to investigate Fam83f's role in hatching and DNA damage response, finding impaired autophagy and increased radiation sensitivity.

This paper describes in-vitro protocols to differentiate mouse and human pluripotent cells into gonadal progenitors, revealing their functional equivalence to in-vivo cells and modeling DSDs.

This study generates and characterizes human pre-neural spinal cord progenitors that can self-renew and differentiate into neural crest cells while adopting rostrocaudal identities.

The paper identifies spatial and molecular differences in cardiac progenitor origins in mouse embryos, showing distinct regions of the primitive streak contribute to different heart structures.

The paper identifies saracatinib as a potent ALK2 inhibitor effective in preventing heterotopic ossification in FOP models.

This study shows maternal factors like Pou5f3 and Sox3 remodel chromatin to define early competence for germ layer formation in Xenopus tropicalis embryos.

The paper investigates zygotic genome activation in frogs, showing that over 1,000 genes activate independently of the N/C ratio and that signaling pathways shape spatial-temporal gene expression patterns.