Emanuela Pasciuto

This study shows Lecanemab reduces amyloid pathology by activating microglia through Fc fragment engagement, enhancing phagocytosis and lysosomal degradation.

The paper uses probabilistic modeling on a parabiosis dataset to analyze lymphocyte migration kinetics and dwell times across tissues, revealing cell type- and tissue-specific residency patterns.

The paper develops a new mouse model for human microglia transplantation to study neurodegenerative diseases and makes it publicly available.

This study shows that delivering IL2 to the brain in aging mice partially restores molecular signatures of aging and improves spatial learning.