James Dooley

AutoSpectral enhances spectral flow cytometry accuracy by optimizing unmixing matrices and matching autofluorescence at the cellular level, significantly reducing errors in complex datasets.

The paper uses probabilistic modeling on a parabiosis dataset to analyze lymphocyte migration kinetics and dwell times across tissues, revealing cell type- and tissue-specific residency patterns.

This paper designs IL2 muteins with enhanced Treg or CD8 T cell specificity and improved production by predicting mutations using SolubiS and testing their functional and structural properties.

This study shows that regulatory T cells protect against age-related retinal inflammation and neurodegeneration by preventing retinal pigment epithelium dysmorphology and phagocyte accumulation in aged mice.

This study shows that delivering IL2 to the brain in aging mice partially restores molecular signatures of aging and improves spatial learning.

This study shows that ageing impairs regulatory T cells' ability to promote remyelination by reducing their capacity to drive oligodendrocyte differentiation and myelination.

This study uses machine learning to identify an immunological signature specific to Juvenile Idiopathic Arthritis (JIA) with ~90% diagnostic accuracy.