Erin Osborne Nishimura

Differential mRNA localization of karyopherin-β2 homologs in C. elegans and humans

The paper compares mRNA localization of karyopherin-β2 homologs in C. elegans and humans, finding that human orthologs do not localize to the nuclear envelope like their C. elegans counterpart.

The SPN-4 Rbfox RNA-binding protein selects maternal mRNAs for CCR4-NOT-dependent clearance in early Caenorhabditis elegans embryos

The paper identifies SPN-4 as a specificity factor for CCR4-NOT-dependent clearance of maternal mRNAs in C. elegans embryos, showing its role in targeting specific transcripts for decay.

Transcriptomic profiling of the embryonic C. elegans intestine with single-cell resolution

This study uses single-cell RNA sequencing to analyze the embryonic C. elegans intestine, identifying 13 cell clusters and their developmental and spatial characteristics.

erm-1 mRNA and ERM-1 protein co-translationally localize to the plasma membrane through a microtubule- and BMK-1-dependent pathway

Altered histone modifications in Aedes aegypti following Rift Valley fever virus exposure

This study identifies changes in histone modifications H3K27ac and H3K9me3 in Aedes aegypti mosquitoes following Rift Valley fever virus exposure, linking these changes to gene expression patterns that support viral replication and host responses.

A single-cell atlas of the Culex tarsalis midgut during West Nile virus infection

This study creates a single-cell atlas of Culex tarsalis midgut cells during West Nile virus infection, revealing cell-type-specific differences in viral replication and immune responses.

Transcriptome profiling of the Caenorhabditis elegans intestine reveals that ELT-2 negatively and positively regulates intestinal gene expression within the context of a gene regulatory network

The paper identifies ELT-2's role in regulating intestinal gene expression in C. elegans by analyzing transcriptome profiles across developmental stages and reveals its dual activation and repression of target genes.

Translation of the ERM-1 membrane-binding domain directs erm-1 mRNA localization to the plasma membrane in the C. elegans embryo

The paper shows that erm-1 mRNA localization to the plasma membrane in C. elegans embryos depends on translation of its membrane-binding domain, with a smiFISH screen identifying additional membrane-localized mRNAs.

mRNA localization is linked to translation regulation in the Caenorhabditis elegans germ lineage

The paper shows that mRNA localization to P granules in C. elegans embryos is linked to translational repression, not just a downstream effect.