The paper compares epigenetic aging estimates between the 450K and EPICv2 arrays, finding that some clocks are affected by missing probes, but overall correlations remain strong.

Mechanisms of Ageing and Development · Dec 5, 2025Peer-reviewedGenetics

Unique epigenomic signatures identify biologically significant subtypes of MDS and predict response to azacitidine

Qin Yang, Miguel Torres‐Martín, Masataka Taguchi, Alice Brogi, Irene Casalin, Eleonora Ceneri, Stephanie Halene, Amy Elizabeth Dezern, Elizabeth A. Griffiths, Matilde Y. Follo, Carlo Finelli, Jerald P. Radich, Michael J. Rauh, Rafael L. Bejar, Mikkael Aaron Sekeres, , María E. Figueroa

This study identifies epigenetic subtypes of MDS using DNA methylation patterns and develops a predictive signature for azacitidine response.

bioRxiv · Apr 23, 2025 · PreprintCancer Biology

Implications of TP53 Allelic State for Genome Stability, Clinical Presentation and Outcomes in Myelodysplastic Syndromes

Elsa Bernard, Yasuhito Nannya, Robert Paul Hasserjian, Sean M. Devlin, Heinz Tuechler, Juan Santiago Medina-Martinez, Tetsuichi Yoshizato, Yusuke Shiozawa, Ryunosuke Saiki, Luca Malcovati, Max Fine Levine, Juan E. Arango, Yangyu Zhou, Francesc Gessé Solé, Catherine A. Cargo, , Elli Papaemmanuil

The paper examines TP53 allelic states in MDS patients, finding that bi-allelic targeting is linked to worse outcomes, while mono-allelic targeting does not differ from wild-type patients.

Nature Medicine · Aug 3, 2020Peer-reviewedGenomics