Author

Michael J. Rauh

Queen's UniversityORCID 0000-0002-8346-5537Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Genetic & Genomic Medicine· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Organism:human· 4 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:benchmarking· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Caitlyn VlasschaertiD· 3 shared Marco M. ButtigiegiD· 3 shared Alexander G. BickiD· 2 shared Yash PershadiD· 2 shared Aarushi GuptaiD· 1 shared Aladdin H. ShadyabiD· 1 shared Alex P. ReineriD· 1 shared Alice Brogi· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Caitlyn VlasschaertORCID

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Author profile →

4 papers

Recent·Most cited

Clonal Hematopoiesis Accelerates Frailty and Functional Decline

Kun Zhao, Candice Quin, Yash Pershad, Liying Xue, Weizhi Cao, Grace I. Bowman, Caitlyn Vlasschaert, Robert W. Corty, Jonathan Brett Heimlich, Erica N. DeJong, Caitlin Lee, Zil Patel, Marco M. Buttigieg, Chris P. Verschoor, Calum A Bane, , Alexander G. Bick

This study links clonal hematopoiesis to accelerated frailty and functional decline across multiple organ systems in humans.

medRxiv · Oct 1, 2026 · PreprintGenetic & Genomic Medicine

Hematopoietic Tet2 inactivation enhances the response to checkpoint blockade immunotherapy

Vincent Rondeau, Suraj Bansal, Marco M. Buttigieg, Andy G.X. Zeng, Darryl Y. Chan, Michelle Chan‐Seng‐Yue, Jin Liqing, Jessica L. McLeod, Meghan Kates, Elisa Donato, Patrick Stelmach, Caitlyn Vlasschaert, Yitong Yang, Aarushi Gupta, Sofia Genta, , Robert J. Vanner

This study shows that hematopoietic Tet2 inactivation improves immune checkpoint blockade response in mice and is associated with better clinical outcomes in melanoma patients with TET2-driven clonal hematopoiesis.

Cancer Research · Nov 11, 2025Peer-reviewedCancer Biology

Unique epigenomic signatures identify biologically significant subtypes of MDS and predict response to azacitidine

Qin Yang, Miguel Torres‐Martín, Masataka Taguchi, Alice Brogi, Irene Casalin, Eleonora Ceneri, Stephanie Halene, Amy Elizabeth Dezern, Elizabeth A. Griffiths, Matilde Y. Follo, Carlo Finelli, Jerald P. Radich, Michael J. Rauh, Rafael L. Bejar, Mikkael Aaron Sekeres, , María E. Figueroa

This study identifies epigenetic subtypes of MDS using DNA methylation patterns and develops a predictive signature for azacitidine response.

bioRxiv · Apr 23, 2025 · PreprintCancer Biology

Clonal hematopoiesis associated non-small cell lung cancer risk is potentiated by small particulate matter air pollution

Caitlyn Vlasschaert, Marco M. Buttigieg, Yash Pershad, Matthew Bruce Lanktree, Melinda C. Aldrich, Michael J. Rauh, Alexander G. Bick

This study finds that clonal hematopoiesis of indeterminate potential (CHIP) doubles non-small cell lung cancer (NSCLC) risk in non-smokers, and this risk is further increased by exposure to high levels of PM2.5 air pollution.

medRxiv · Jan 17, 2024 · PreprintGenetic & Genomic Medicine