Nadia R. Roan

The paper develops HIV-seq to capture HIV transcripts for scRNA-seq, revealing distinct transcriptional features of HIV-transcribing cells in viremic and ART-suppressed HIV patients.

This study shows that defective HIV-1 proviruses can reprogram CD4+ T cells by altering BACH2 and STAT5B gene expression, leading to immune evasion and persistence in ART-treated individuals.

The paper introduces Incytr, a method for discovering cell signaling pathways from multi-omics data, demonstrating its application in disease contexts and showing its utility for drug discovery and understanding cell communication.

The paper evaluates whether donor-multiplexed scRNA-seq introduces alloreactive gene expression changes and finds no detectable alloreactivity across three workflows.