Wei‐Hung Jung

This study shows how mechanical forces and substrate properties enhance T-cell receptor proofreading by delaying decision-making and improving ligand discrimination.

This study shows that matrix viscoelasticity affects dendritic cell migration and immune responses by altering actomyosin dynamics and chromatin accessibility.

This study develops a feeder-free method to generate functional human dendritic cells from pluripotent stem cells, outperforming monocyte-derived dendritic cells in antigen presentation and T cell activation.

This study shows that mechanical properties of thymus-mimetic matrices regulate human T-cell differentiation by modulating Notch1 and integrin signaling pathways.