Bruce Edward Torbett

This study evaluates lentiviral vector delivery of SCN1A transgenes, finding that sequence optimization and epigenetic factors affect long-term expression.

This study investigates how Lenacapavir disrupts HIV-1 assembly and maturation, revealing a 'premature' lattice formation that prevents infectious virus production.

MrHAMER2 enables high-accuracy long-read RNA sequencing to detect and quantify viral isoform dynamics during HIV-1 latency in CD4+ T cells.

This study uses atomistic simulations to show how IP6 and PF74 modulate HIV-1 capsid stability by altering hexamer-hexamer tilt angles, revealing distinct effects on structural flexibility.

APHIX automates HIV-1 isoform analysis from long-read RNA sequencing data, providing accurate splice site quantification and non-coding exon detection across multiple HIV strains.

ViReMa is updated to detect recombination events in long-read sequencing data and reports various recombinant species in different viral contexts.

The paper develops a method to sequence full-length host and viral transcripts by ablating 3' RNA ends and using processive reverse transcriptases, improving coverage and detection of long transcripts.

The paper uses CoVaMa to analyze co-variation between SNVs and recombination events in viral genomes, finding correlations in FHV and HIV datasets.

MrHAMER enables accurate long-range viral sequencing, allowing analysis of intra-host evolution and genetic interactions in HIV.

The paper uses a Potts Hamiltonian model to infer epistatic effects in HIV-1 protease mutations, showing how these interactions influence drug resistance and fitness.