Author

Christopher J.P. Mathy

University of California, San FranciscoORCID 0000-0002-5546-9733Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2

Signature Assays, Organisms & Methods

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Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Danielle L. SwaneyiD· 2 shared Gwendolyn Μ. JangiD· 2 shared Hannes BrabergiD· 2 shared Jiewei XuiD· 2 shared Robyn M. KaakeiD· 2 shared Tina PericaiD· 2 shared Advait SubramanianiD· 1 shared Alan D. FrankeliD· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersSystems Biology

Danielle L. SwaneyORCID

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2 papers

Recent·Most cited

Biophysical basis of cellular multi-specificity encoded in a model molecular switch

Tina Perica, Christopher J.P. Mathy, Jiewei Xu, Gwendolyn Μ. Jang, Yang Zhang, Robyn M. Kaake, Noah Ollikainen, Hannes Braberg, Danielle L. Swaney, David G. Lambright, Mark J. S. Kelly, Nevan J. Krogan, Tanja Kortemme

The paper investigates how the GTPase Ran/Gsp1 achieves functional multi-specificity through biophysical and genetic perturbations, revealing that its effects are linked to kinetic parameters of the switch cycle rather than direct interaction sites.

Nature · Oct 13, 2021Peer-reviewedSystems Biology

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

David Ezra Gordon, Gwendolyn Μ. Jang, Mehdi Bouhaddou, Jiewei Xu, Kirsten Obernier, Kris M. White, Matthew J. O’Meara, Veronica V. Rezelj, Jeffrey Z. Guo, Danielle L. Swaney, Tia A. Tummino, Ruth Hüttenhain, Robyn M. Kaake, Alicia Richards, Beril Tutuncuoglu, , Natalia Jura

Affinity-purification mass spectrometry of 26 SARS-CoV-2 proteins in HEK293T cells yields 332 high-confidence host interactions and 67 druggable human proteins with known compounds.

Nature · Apr 30, 2020Peer-reviewedSystems Biology✦ In-depth digest