Natalia Jura

Structures of the PI3Kα/KRas complex on lipid bilayers reveal the molecular mechanism of PI3Kα activation

The paper presents cryo-EM structures of the PI3Kα/KRas complex on lipid bilayers, revealing the conformational changes and molecular mechanisms of PI3Kα activation.

Autoregulation of the MET Receptor Tyrosine Kinase by its Intracellular Juxtamembrane Domain

This study identifies a role for the MET juxtamembrane domain in accelerating kinase activation through an allosteric mechanism, with implications for MET-driven cancer therapies.

CNPY4 is a Lipid-Binding Regulator of Sphingolipid Homeostasis

This study identifies CNPY4 as a sphingolipid-binding protein that regulates sphingolipid levels and distribution, impacting cholesterol homeostasis and cellular signaling.

Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning

The paper uses deep mutational scanning to analyze MET kinase domain mutations and their resistance to 11 inhibitors, identifying resistance and sensitizing mutations and improving prediction with a protein language model.

Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain.

Human ACE2 receptor polymorphisms predict SARS-CoV-2 susceptibility

This study identifies ACE2 receptor polymorphisms that may influence susceptibility to SARS-CoV-2 by altering the interaction between ACE2 and the viral S-protein.

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

Affinity-purification mass spectrometry of 26 SARS-CoV-2 proteins in HEK293T cells yields 332 high-confidence host interactions and 67 druggable human proteins with known compounds.