Author

David G. Lambright

University of Massachusetts Chan Medical School

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Anupam MondaliD· 1 shared Christopher J.P. MathyiD· 1 shared Danielle L. SwaneyiD· 1 shared Eric M. MorrowiD· 1 shared Gwendolyn Μ. JangiD· 1 shared Hannes BrabergiD· 1 shared Hasib Aamir RiaziD· 1 shared Jeetain MittaliD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCell Biology

Anupam MondalORCID

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Author profile →

2 papers

Recent·Most cited

Endosome maturation is orchestrated by inside-out proton signaling through a Na+/H+ exchanger and pH-dependent Rab GTPase cycling

Youjin Lee, Qing Ouyang, Li Ma, Morgan Fleishman, Hasib Aamir Riaz, Michael Schmidt, Jeffrey L. Dupree, Anupam Mondal, Priyesh Mohanty, Jeetain Mittal, Oliver Beckstein, David G. Lambright, Eric M. Morrow

The paper shows that endosome maturation is regulated by proton signaling through NHE6 and pH-dependent Rab7 cycling, with implications for neurodegeneration.

Nature Communications · May 8, 2026Peer-reviewedCell Biology

Biophysical basis of cellular multi-specificity encoded in a model molecular switch

Tina Perica, Christopher J.P. Mathy, Jiewei Xu, Gwendolyn Μ. Jang, Yang Zhang, Robyn M. Kaake, Noah Ollikainen, Hannes Braberg, Danielle L. Swaney, David G. Lambright, Mark J. S. Kelly, Nevan J. Krogan, Tanja Kortemme

The paper investigates how the GTPase Ran/Gsp1 achieves functional multi-specificity through biophysical and genetic perturbations, revealing that its effects are linked to kinetic parameters of the switch cycle rather than direct interaction sites.

Nature · Oct 13, 2021Peer-reviewedSystems Biology