Hideki Uosaki

Cardiac progenitors auto-regulate second heart field cell fate via Wnt secretion

The paper identifies cardiac progenitors as a source of Wnts that regulate second heart field development through secretion, using genetic manipulation and single-cell RNA sequencing in mice.

Cross-organ transcriptomic comparison reveals universal factors during maturation

The paper identifies universal gene pathways and regulators involved in organ maturation across four mouse tissues.

Noncanonical Notch signals have opposing roles during cardiac development

This study shows noncanonical Notch signaling has stage-specific roles in cardiac development, inhibiting early heart formation but promoting later growth.

PGC1/PPAR Drive Cardiomyocyte Maturation through Regulation of Yap1 and SF3B2

This study identifies PGC1/PPAR signaling and its regulators Yap1 and SF3B2 as key drivers of cardiomyocyte maturation through single-cell transcriptomic analysis across neonatal to adult hearts.

Disentangling the biological information encoded in disordered mitochondrial morphology through its rapid elicitation by iCMM

This study introduces iCMM, a method to rapidly manipulate mitochondrial morphology, revealing its rapid impact on biological information reconstitution.