Takashi Matsuzaka

Label-free imaging of intracellular structures in living mammalian cells via external apodization phase-contrast microscopy

This study introduces ExAPC microscopy for label-free visualization of intracellular structures, showing its ability to resolve biomolecular condensates, lipid droplets, and mitochondria with high spatiotemporal resolution.

Rhomboid protease RHBDL4/RHBDD1 cleaves SREBP-1c at ER monitoring and regulating fatty acids

The paper shows RHBDL4 cleaves SREBP-1c at the ER, with its activity modulated by fatty acid types, and demonstrates its role in lipid homeostasis.

Disentangling the biological information encoded in disordered mitochondrial morphology through its rapid elicitation by iCMM

This study introduces iCMM, a method to rapidly manipulate mitochondrial morphology, revealing its rapid impact on biological information reconstitution.