A functionally conserved mechanism of modulation via a vestibule site in pentameric ligand-gated ion channels
Marijke Brams, Cédric Govaerts, Kumiko Kambara, Kerry L. Price, Radovan Spurný, Anant Gharpure, Els Pardon, Genevieve L. Evans, Daniel Bertrand, Sarah C. R. Lummis, Ryan E. Hibbs, Jan Steyaert, Chris Ulens
The paper identifies a conserved vestibule binding site in pLGICs and shows nanobodies can act as allosteric modulators, expanding drug design possibilities.
bioRxiv · Sep 17, 2019 · PreprintNeuroscience