This study tracks DNA damage and chromatin remodeling in live cells using Hoechst-based imaging, showing PARP1 dynamics and chromatin relaxation kinetics.

Cellular and Molecular Life Sciences · Feb 16, 2026Peer-reviewedBiophysics

SPROUTS_DB: an implemented database of contaminants for extracellular vesicle proteomics studies

Maria Gaetana Giovanna Pittalà, Loredana Leggio, Greta Paternò, Elena Giusto, Laura Civiero, Vincenzo Cunsolo, Silvia Vivarelli, Antonella Di Francesco, Emanuele Alpi, Nunzio Iraci, Rosaria Saletti

SPROUTS_DB catalogs serum-derived contaminants in extracellular vesicle proteomics to improve data reliability by distinguishing contaminants from true proteins.

bioRxiv · May 20, 2025 · PreprintCell Biology

Small Extracellular Vesicles Secreted by Region-specific Astrocytes Ameliorate the Mitochondrial Function in a Cellular Model of Parkinson's Disease

Loredana Leggio, Francesca L’Episcopo, Andrea Magrì, María José Ulloa-Navas, Greta Paternò, Silvia Vivarelli, Carlos A. P. Bastos, Cataldo Tirolo, Nunzio Testa, Salvatore Caniglia, Pierpaolo Risiglione, Fabrizio Pappalardo, Nuno Faria, Luca Peruzzotti‐Jametti, Stefano Pluchino, , Nunzio Iraci

The paper investigates the neuroprotective effects of small extracellular vesicles from region-specific astrocytes in Parkinson's disease, showing they improve mitochondrial function.

bioRxiv · Apr 23, 2021 · PreprintNeuroscience