Author

Yifan Kong

University of KentuckyORCID 0000-0002-5650-8079Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Yifan Kong3 papers · Kunming Institute of Zoology

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:metabolism & bioenergetics· 1 Assay:proteomics· 1

Frequent Co-Authors

C.N.R. RaoiD· 1 shared Campbell McInnesiD· 1 shared Cassidy E Socia· 1 shared Chaohao LiiD· 1 shared Danda P. ChapagaiiD· 1 shared Derek B. AllisoniD· 1 shared Elmar NurmemmedoviD· 1 shared Fengyi MaoiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

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2 papers

Recent·Most cited

Abbapolin inhibitors of the PLK1 PBD as Prostate Cancer Therapeutics, in vivo activity and synergy with androgen therapy

George Merhej, Gurusankar Ramamoorthy, Danda P. Chapagai, Mohammad Esfini Farahani, Yifan Kong, C.N.R. Rao, Jessy M. Stafford, Zachary T. Mack, Cassidy E Socia, S Krishna Kumari, Kristen Hogan, Niti Jan, Maria Marjorette Pena, Elmar Nurmemmedov, Ivan Babić, , Campbell McInnes

This study develops and characterizes abbapolins, non-peptidic PLK1 PBD inhibitors, showing in vivo efficacy against prostate cancer and synergy with enzalutamide.

bioRxiv · Jul 24, 2026 · PreprintCancer Biology

Dysregulation of mitochondrial function by PLK1-mediated PDHA1 phosphorylation promotes Cr(VI)-associated lung cancer progression

Qiongsi Zhang, Jia Peng, Zhiguo Li, Xiongjian Rao, Derek B. Allison, Qi Qiao, Zhuangzhuang Zhang, Yifan Kong, Yanquan Zhang, Ruixin Wang, Jinghui Liu, Xinyi Wang, Chaohao Li, Fengyi Mao, Qing Shao, , Xiaoqi Liu

This study shows that PLK1-mediated PDHA1 phosphorylation impairs mitochondrial function and promotes Cr(VI)-induced lung cancer progression by disrupting energy metabolism and apoptosis.

Journal of Biological Chemistry · Jun 20, 2025Peer-reviewedCancer Biology