Michael H. Herschl

A combinatorial domain screening platform reveals epigenetic effector interactions for transcriptional perturbation

The paper introduces COMBINE, a platform that screens epigenetic effector domain pairs to identify synergistic and antagonistic interactions, revealing new mechanisms for transcriptional regulation.

Designing Cell-Type-Specific Promoter Sequences Using Conservative Model-Based Optimization

The paper introduces a framework for designing cell-type-specific promoters using model-based optimization, demonstrating improved specificity in blood cancer cell lines.

Strategies for effectively modelling promoter-driven gene expression using transfer learning

This paper develops transfer learning strategies to model promoter-driven gene expression in understudied cell types, showing improvements in performance with pretraining and transfer.

Dynamic spreading of chromatin-mediated gene silencing and reactivation between neighboring genes in single cells

The paper studies how gene silencing and reactivation spread between neighboring genes in single cells, finding different dynamics based on chromatin regulators and insulator elements.