Hyungseok C. Moon

BioReason-Pro: Advancing Protein Function Prediction with Multimodal Biological Reasoning

A reasoning LLM combining ESM3 embeddings with GO-GPT term predictions produces protein function annotations that experts rated tie-or-better than UniProt in 79% of cases (SFT model).

A combinatorial domain screening platform reveals epigenetic effector interactions for transcriptional perturbation

The paper introduces COMBINE, a platform that screens epigenetic effector domain pairs to identify synergistic and antagonistic interactions, revealing new mechanisms for transcriptional regulation.

Decoding Arc Transcription: A Live-Cell Study of Stimulation Patterns and Transcriptional Output

This study uses live-cell imaging to show that 10 Hz electrical stimulation maximizes Arc transcription and correlates with calcium transients, but calcium alone does not fully explain Arc induction.

Real-time visualization of mRNA synthesis during memory formation in live animals

The paper uses a genetically-encoded RNA indicator to visualize Arc mRNA dynamics in live animals during memory formation and retrieval, revealing rapid turnover in hippocampal neurons and stable expression in retrosplenial cortex neurons.