The paper investigates the role of SET1/COMPASS and condensin in meiotic chromosome organization in C. elegans using fluorescence lifetime imaging microscopy.

bioRxiv · May 26, 2020 · PreprintGenetics

CTCF controls imprinted gene activity at the mouse Dlk1-Dio3 and Igf2- H19 domains by modulating allele-specific sub-TAD structure

David Llères, Benoît Moindrot, Rakesh Pathak, Vincent Piras, Mélody Matelot, Benoît Pignard, Alice Marchand, Mallory Poncelet, Aurélien Perrin, Virgile Tellier, Robert Feil, Daan Noordermeer

The paper investigates how CTCF modulates sub-TAD structure at imprinted domains in mice, affecting gene activity through allele-specific binding.

Genome biology · Dec 1, 2019Peer-reviewedMolecular Biology

Heterochromatin delays CRISPR-Cas9 mutagenesis but does not influence repair outcome

Kallimasioti Pazi, Keerthi T. Chathoth, Gillian C.A. Taylor, Alison M. Meynert, Tracy J. Ballinger, Martijn J. E. Kelder, Sébastien Lalevée, Ildem Sanli, Robert Feil, Andrew J. Wood

The paper shows heterochromatin slows CRISPR-Cas9 mutagenesis but does not affect repair outcomes, with mutagenesis inhibition depending on Cas9 exposure levels.

PLoS Biology · Dec 12, 2018Peer-reviewedGenetics