Anna A. Schwendeman

Reprogramming the Immune Suppressive Tumor Microenvironment in Glioma Enhances the Efficacy of Immune-Mediated Gene Therapy

This study shows that combining CD73 inhibition with immune-stimulatory gene therapy improves treatment efficacy for wtIDH1 gliomas.

Targeting NF-κB epigenetic activation and DNA repair deficiency in G34-mutant pediatric diffuse hemispheric glioma with nanoparticles combining PARP inhibition and immune stimulation mediated by CpG dinucleotides

ApoE-Dependent Lipid Handling by Median Eminence Microglia Preserves Myelin Integrity and Metabolic Function

This study identifies ApoE-dependent lipid handling in median eminence microglia that preserves myelin integrity and metabolic function, showing therapeutic potential through liver X receptor activation.

HDL Nanodiscs Loaded with Liver X Receptor Agonist Decreases Tumor Burden and Mediates Long-term Survival in Mouse Glioma Model

This study shows that HDL nanodiscs with LXR agonists and CpG oligonucleotides improve survival and reduce tumor burden in a mouse glioma model when combined with radiation.

Physico-chemical principles of HDL-small RNA binding interactions.

The paper investigates how HDL binds to single-stranded small RNAs through interactions with apoA-I, revealing mechanisms that may enable extracellular RNA communication.