Andrés Tapia del Fierro

Suv39h-catalysed H3K9me3 is critical for euchromatic genome organisation and the maintenance of gene transcription

This study shows that Suv39h enzymes are essential for organizing euchromatic regions and maintaining gene transcription by tethering H3K9me3 domains to the nuclear lamina.

SMCHD1 has separable roles in chromatin architecture and gene silencing that could be targeted in disease

This study identifies a mutation in SMCHD1 that enhances gene silencing and disrupts developmental processes, revealing distinct roles of SMCHD1 in chromatin structure and gene regulation.

Maternal SMCHD1 regulates Hox gene expression andpatterning in the mouse embryo

This study shows maternal SMCHD1 prevents premature Hox gene activation in mouse embryos, leading to posterior homeotic transformations when absent.

Smchd1 is a maternal effect gene required for autosomal imprinting

This study identifies Smchd1 as a maternal effect gene that regulates imprinted expression of 16 genes by translating polycomb-mediated histone methylation marks into a heritable chromatin state.