Wing Fuk Chan

The long non-coding RNA Dreg1 is required for optimal ILC2 development

This study identifies Dreg1 as a non-coding RNA essential for ILC2 development, regulated by Tcf1 and influencing Gata3 expression levels.

Suv39h-catalysed H3K9me3 is critical for euchromatic genome organisation and the maintenance of gene transcription

This study shows that Suv39h enzymes are essential for organizing euchromatic regions and maintaining gene transcription by tethering H3K9me3 domains to the nuclear lamina.

Survey of activation-induced genome architecture reveals a novel enhancer of Myc

The paper identifies a novel Myc enhancer activated in B cells shortly after activation but finds it is not essential for Myc expression or cell proliferation.

Activation of stably silenced genes by recruitment of a synthetic de-methylating module

This study develops a synthetic de-methylating module to reactivate stably silenced genes by combining TET1's demethylating activity with transcriptional activators.

Genome reorganization prior to mitosis shapes the generation of adaptive immunity

The paper shows genome reorganization occurs in discrete waves before DNA replication and mitosis, controlling B cell differentiation into plasma cells.