Lachlan W. Whitehead

A necroptotic-to-apoptotic signaling axis underlies inflammatory bowel disease

This study identifies dysregulated epithelial cell death signaling in inflammatory bowel disease, showing it persists during remission despite therapy.

Formation of the moving junction is the nexus for host cytoskeletal remodelling during Plasmodium falciparum invasion of human erythrocytes

This study investigates how Plasmodium falciparum bypasses the erythrocyte cytoskeleton during invasion by analyzing the timing of cytoskeletal disassembly and apical organelle release using lattice light sheet microscopy.

Differentiation of Toxoplasma into latent forms is linked to central carbon metabolism and requires a GID/CTLH-type E3 ubiquitin ligase

This study identifies glucose-limiting conditions and a GID/CTLH-type E3 ubiquitin ligase as key factors in Toxoplasma differentiation into latent forms.

Suv39h-catalysed H3K9me3 is critical for euchromatic genome organisation and the maintenance of gene transcription

This study shows that Suv39h enzymes are essential for organizing euchromatic regions and maintaining gene transcription by tethering H3K9me3 domains to the nuclear lamina.

Reflective multi-immersion microscope objectives inspired by the Schmidt telescope

The paper introduces a novel Schmidt objective for high-resolution imaging in cleared tissues, achieving high NA, long WD, and large FOV with only two optical elements.

High-Resolution, Large Imaging Volume, and Multi-View Single Objective Light-Sheet Microscopy

This paper introduces a novel single objective light-sheet microscope that achieves high resolution, large field of view, and multi-view imaging for various biological systems.