Christine R. Keenan

This study characterizes MORC2 phosphorylation's role in DNA compaction and chromatin remodelling, showing it regulates ATP hydrolysis and DNA binding.

This study shows that Suv39h enzymes are essential for organizing euchromatic regions and maintaining gene transcription by tethering H3K9me3 domains to the nuclear lamina.

The paper identifies a novel Myc enhancer activated in B cells shortly after activation but finds it is not essential for Myc expression or cell proliferation.

This study develops a synthetic de-methylating module to reactivate stably silenced genes by combining TET1's demethylating activity with transcriptional activators.

The paper shows genome reorganization occurs in discrete waves before DNA replication and mitosis, controlling B cell differentiation into plasma cells.