Kelsey E. Huntington

This study shows that combining ONC201 with ATR inhibitor ceralasertib synergistically kills ovarian cancer cells by inducing apoptosis and reducing anti-apoptotic proteins.

This study identifies a 12-gene BTB signature, shows CDH5 as a core component, and demonstrates that BIA disrupts the BTB to enhance chemotherapy delivery and efficacy in GBM.

This study shows that combining TLY012 with PD-1 inhibition reduces PDAC tumor growth in mice by enhancing proinflammatory cytokines and immune cell infiltration.

This study shows that combining ONC201 with enzalutamide or darolutamide synergistically reduces mCRPC cell viability and PSA levels, with in vivo anti-tumor effects.