Robert W. Maples

The paper shows that the circadian clock programs antiviral immunity in the intestine, affecting susceptibility to enteric virus infection based on the time of day.

The paper constructs a single-cell atlas of mouse intestinal immune cells across the day-night cycle, revealing circadian dynamics in gene expression and cell populations.

This study shows that the β2-adrenergic receptor regulates circadian gene oscillation and daily timing of cytolytic T cell responses to virus infection.

The paper identifies an egress-enhancing mutation in murine norovirus that increases replication speed and viral titers in mice.

This study shows a single amino acid change in a reovirus alters its infection outcome in mice with microbiota depletion, affecting tropism and sensitivity to microbiota-driven antiviral responses.

This study identifies mutations in murine norovirus that enhance replication in human cells, revealing post-entry restrictions in addition to receptor expression.