Qing Cheng

Sodium Aurothiomalate Induces Ferroptosis by Targeting GPX4 via Gold-Dependent Thiomalate Covalent Modification

This study shows sodium aurothiomalate induces ferroptosis by covalently modifying GPX4 through a gold-dependent mechanism, leading to tumor growth reduction in preclinical models.

The transsulfuration pathway suppresses the embryonic lethalphenotype of glutathione reductase mutants in Caenorhabditis elegans

The paper shows that inactivating the NMD pathway suppresses the embryonic lethality of gsr-1 mutants in C. elegans by enabling the transsulfuration pathway to compensate for the loss of glutathione reductase function.

Ancient loss of catalytic selenocysteine spurred convergent adaptation in a mammalian oxidoreductase

The paper reconstructs and assays ancient enzymes to show that losing selenocysteine in GPX6 led to functional loss and convergent evolution in mammalian oxidoreductases.