Rebecca Harris

The paper develops a computational pipeline to identify drug targets for SOX2-dependent lung cancer using multi-modal data and validates them in vitro.

This study investigates neurodegeneration in Xeroderma pigmentosum using stem cell-derived neurons, identifying endoplasmic reticulum stress and UPS dysfunction as key factors and developing an early detection assay.

This study shows that long-term culture of human intestinal organoids leads to DNA methylation changes, altered gene expression, and functional shifts, suggesting potential confounding effects in research.

The paper identifies gene-specific mutational signatures caused by replication errors and endogenous DNA damage using CRISPR-Cas9 knockouts and whole-genome sequencing.

The paper identifies overlapping Pax5 and c-Myb binding sites in the FBXO7 promoter that regulate its expression in B cells.