Heike Laman

State-selective inhibition of alpha-synuclein aggregation by de novo oligomer-binding proteins

This study designs de novo proteins that selectively inhibit alpha-synuclein aggregation by targeting specific intermediates, with one binder preferentially inhibiting oligomer formation and secondary nucleation.

Combinatorial screening of biological degrader modules identifies heterobifunctional molecules that efficiently destroy MYC, leading to rapid tumour cell death in vitro and in vivo

Restoration of Fbxo7 expression in dopaminergic neurons restores tyrosine hydroxylase in a mouse model of Parkinson's disease

This study shows that restoring Fbxo7 expression in dopaminergic neurons of a mouse Parkinson's model rescues tyrosine hydroxylase levels in the striatum and nucleus accumbens.

Study of an FBXO7 patient mutation reveals Fbxo7 and PI31 co-regulate proteasomes and mitochondria

This study identifies an FBXO7 mutation that disrupts its interaction with PI31, affecting proteasome and mitochondrial function in patient cells.

Analysis of the FBXO7 promoter reveals overlapping Pax5 and c-Myb binding sites functioning in B cells

The paper identifies overlapping Pax5 and c-Myb binding sites in the FBXO7 promoter that regulate its expression in B cells.

A conserved requirement for Fbxo7 during male germ cell cytoplasmic remodelling

This paper shows that Fbxo7 is required for male fertility in mice, as its deficiency leads to sterile males with abnormal spermatid disposal during spermiogenesis.