Marina Lavigne

D2-expressing neurons of the anterior paraventricular nucleus of the thalamus as key players for modulating relative aversive and safety learning

This study identifies aPVT D2+ neurons as critical for computing relative aversive and safety value signals during learning to guide value-based choices.

Motivational control is implemented by a cingulo-prefrontal pathway

This study shows that activating the MCC-dlPFC pathway in macaques increases foraging task engagement without changing trial-to-trial adaptive strategies.

Noradrenergic signaling in the rodent orbitofrontal cortex is required to update goal-directed actions.

This study shows that noradrenergic projections to the rodent orbitofrontal cortex are necessary for updating action-outcome relationships during reversal learning.

Noradrenergic cross-modular reciprocal inhibition within the Locus Coeruleus.

This study investigates how noradrenaline release within the Locus Coeruleus modulates cross-modular interactions through reciprocal inhibition and rebound activity.

Locus-coeruleus norepinephrine activity gates sensory-evoked awakenings from sleep

This study shows that locus-coeruleus norepinephrine activity determines the likelihood of sensory-evoked awakenings from sleep, with reduced activity during sleep suppressing responses to auditory stimuli.