Bao Gia Vu

Similarities and distinctions in the activation of the Candida glabrata Pdr1 regulatory pathway by azole and non-azole drugs

This study investigates how azole and phenothiazine drugs activate the C. glabrata Pdr1 pathway, showing distinct kinetics and mechanisms of CDR1 induction.

Rapid, efficient auxin-inducible protein degradation in Candida pathogens

This paper demonstrates the efficient use of auxin-inducible degradation systems in Candida pathogens for rapid protein inactivation.

Multiple mechanisms impact fluconazole resistance of mutant Erg11 proteins in Candida glabrata

This study identifies ERG11 mutations in Candida glabrata that confer azole resistance through altered enzyme activity and activation of Pdr1-mediated resistance mechanisms.

Azole resistance is mediated by integration of sterol gene regulation and membrane transporter production by the zinc cluster-containing transcription factor Upc2A in Candida glabrata

This paper identifies Upc2A as a master regulator in Candida glabrata that coordinates sterol biosynthesis and membrane transporter production to mediate azole resistance.