Scott Moye-Rowley

This study identifies Ypk2 as a multidrug susceptibility factor in C. glabrata by showing its role in modulating gene expression and drug resistance across antifungal classes.

This study shows that HosA, a histone deacetylase in A. fumigatus, regulates stress resistance, host cell interactions, and virulence by modulating gene expression related to secondary metabolism and energy metabolism.

This paper introduces a method to regulate proteolysis of GFP fusion proteins in A. fumigatus using a nanobody-Rnf4 fusion protein, enabling direct protein level manipulation.

This study investigates how azole and phenothiazine drugs activate the C. glabrata Pdr1 pathway, showing distinct kinetics and mechanisms of CDR1 induction.

The paper identifies coactivator proteins that interact with the hyperactive Pdr1 transcription factor in Candida glabrata and shows their necessity for Pdr1-dependent gene transcription and azole resistance.

The paper identifies a conserved C-terminal region in AtrR that is required for gene-specific activation of abcG1 and other membrane transporter genes but not cyp51A, revealing distinct mechanisms of AtrR-mediated transcription.

This paper demonstrates the efficient use of auxin-inducible degradation systems in Candida pathogens for rapid protein inactivation.

The paper investigates the interaction between transcription factors FfmA and AtrR in Aspergillus fumigatus, showing their physical and genetic interaction affects gene expression and azole resistance.

This study identifies ERG11 mutations in Candida glabrata that confer azole resistance through altered enzyme activity and activation of Pdr1-mediated resistance mechanisms.

This paper identifies Upc2A as a master regulator in Candida glabrata that coordinates sterol biosynthesis and membrane transporter production to mediate azole resistance.