Daniel Eidelberg Spratt

Increasing Cancer Stemness Drives Prostate Cancer Progression, Plasticity, Therapy Resistance and Poor Patient Survival

This study quantifies cancer stemness in prostate cancer across progression stages, showing its association with therapy resistance, poor survival, and lineage plasticity.

Genomic Determinants of Lethality and Therapeutic Vulnerability in Castration-Resistant Prostate Cancer

This study identifies genomic drivers of progression and therapeutic outcomes in mCRPC and develops a multi-omic classifier to predict patient survival across multiple therapies.

Deep phenotyping of the prostate tumor microenvironment reveals molecular stratifiers of relapse and links inflammatory chemokine expression to aberrant metabolism

The paper identifies molecular signatures in prostate cancer that link inflammatory chemokine expression to metabolic changes and relapse risk.

MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets

This study shows MYC overexpression disrupts AR transcriptional pause release, promoting aggressive prostate cancer progression.