Author

Ryan James Rebernick

University of MichiganORCID 0000-0002-5532-581XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Assay:proteomics· 2 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Abhijit ParoliaiD· 2 shared Arul M. ChinnaiyaniD· 2 shared Dan R. RobinsoniD· 2 shared Sumeet A. SolankiiD· 2 shared Wesley HuangiD· 2 shared Xuhong CaoiD· 2 shared Yatrik Madhukar ShahiD· 2 shared Yi‐Mi WuiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

Abhijit ParoliaORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Genomic Determinants of Lethality and Therapeutic Vulnerability in Castration-Resistant Prostate Cancer

Ryan James Rebernick, Liat Hammer, Mahnoor Naseer Gondal, Abhijit Parolia, Yi‐Mi Wu, Noshad Hosseini, Matthew J. Schipper, Anbarasu Kumaraswamy, Matthew McFarlane, Xuhong Cao, Phillip Lee Palmbos, Megan E.V. Caram, David Carl Smith, Sarah Elizabeth Yentz, MI-OncoSeq Team, , Marcin Cieslik

This study identifies genomic drivers of progression and therapeutic outcomes in mCRPC and develops a multi-omic classifier to predict patient survival across multiple therapies.

bioRxiv · Jun 20, 2026 · PreprintCancer Biology

Fatty acids in the tumor microenvironment reprogram neutrophils to induce immunosuppression via adenosine

Rashi Singhal, Nina W. Zhang, Zheng Hong Lee, Hannah Noelle Bell, Prarthana Dalal, Sumeet A. Solanki, Wesley Huang, Ryan James Rebernick, Peter Sajjakulnukit, Himani Jasewicz, Roshan Kumar, Nikhil Kumar Kotla, Amanda Huber, Anitha Vijay Mallappa, Subhash B. Arya, , Yatrik Madhukar Shah

This study identifies a fatty acid-driven neutrophil-adenosine axis that promotes immunosuppression in colorectal cancer and shows that targeting adenosine receptors can enhance immunotherapy responses.

bioRxiv · Apr 6, 2026 · PreprintCancer Biology

Fmo5 plays a sex-specific role in goblet cell maturation and mucus barrier formation

Megan L. Schaller, Madeline M. Sykes, Joy Mecano, Sumeet A. Solanki, Wesley Huang, Ryan James Rebernick, Safa Beydoun, Emily Wang, Amara Bugarin-Lapuz, Yatrik Madhukar Shah, Scott F. Leiser

This study identifies Fmo5's sex-specific role in goblet cell maturation and mucus barrier formation in the intestine, with severe effects in female mice.

Cellular and Molecular Gastroenterology and Hepatology · Jan 1, 2025Peer-reviewedPhysiology

CDK12 Loss Promotes Prostate Cancer Development While Exposing Vulnerabilities to Paralog-Based Synthetic Lethality

Jean Ching-Yi Tien, Jie Luo, Yu Chang, Yuping Zhang, Yunhui Cheng, Xiaoju Wang, Jianzhang Yang, Rahul Mannan, Somnath Mahapatra, Palak Shah, Xiao-Ming Wang, Abigail J. Todd, Sanjana Eyunni, Caleb Cheng, Ryan James Rebernick, , Arul M. Chinnaiyan

This study shows CDK12 loss drives prostate cancer development and identifies CDK13 as a therapeutic target through paralog-based synthetic lethality in CDK12-mutant tumors.

Cell Reports Medicine · Oct 1, 2024Peer-reviewedCancer Biology