Thomas D. Als

Genome-wide association study identifies new loci associated with OCD

This study conducts a large-scale GWAS of OCD, identifying 15 new genome-wide significant loci and linking OCD to multiple cortical regions and cell types.

Identification of 64 new risk loci for major depression, refinement of the genetic architecture and risk prediction of recurrence and comorbidities

This study identifies 64 new risk loci for major depression, refines its genetic architecture, and shows strong genetic overlap with other psychiatric disorders and educational attainment.

Genome-wide association study of school grades identifies a genetic overlap between language ability, psychopathology and creativity

This study identifies genetic overlaps between psychiatric disorders, language ability, and creativity through a GWAS of school grades.

Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia

A genome-wide association study of 69,369 schizophrenia cases and 236,642 controls identifies 270 risk loci, prioritizes 130 genes, and links common and rare risk variants to neuronal synaptic biology.

Genome-wide by environment interaction study of stressful life events and hospital-treated depression in the iPSYCH2012 sample

The paper investigates genome-wide interactions between stressful life events and depression using a case-cohort study, identifying three genome-wide significant loci but lacking replication in an independent sample.

Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology

Meta-analysis of 41,917 European-ancestry bipolar disorder cases versus 371,549 controls yields 64 risk loci (33 novel), neuronal and synaptic gene enrichment, and 15 eQTL-prioritized genes.

Genetic analyses identify widespread sex-differential participation bias

The paper identifies sex-differential participation bias in genetic studies by performing GWAS on sex in 3.3 million individuals, finding 158 loci associated with sex and highlighting traits like BMI that may influence participation.

Meta-analysis of Scandinavian Schizophrenia Exomes

This study performs a meta-analysis of Scandinavian schizophrenia exomes, identifying three genes associated with the disorder and highlighting shared genetic architecture with high-functioning autism.

Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

The paper examines common genetic variants' contribution to bipolar disorder risk in multiplex families and finds higher polygenic risk scores in affected individuals compared to controls and unaffected family members.

The genetics of the mood disorder spectrum: genome-wide association analyses of over 185,000 cases and 439,000 controls

This study identifies 73 genome-wide significant loci for mood disorders, revealing shared and distinct genetic factors between major depressive disorder and bipolar disorder.

Identification of risk variants and characterization of the polygenic architecture of disruptive behavior disorders in the context of ADHD

This study identifies risk variants and characterizes the polygenic architecture of ADHD comorbid with disruptive behavior disorders through a large GWAS meta-analysis.

Genomewide association study identifies 30 loci associated with bipolar disorder

This study identifies 30 genome-wide significant loci associated with bipolar disorder, including novel genes involved in ion channels, neurotransmitters, and synaptic components.

Common risk variants identified in autism spectrum disorder

This study identifies five genome-wide significant loci and seven shared with other traits in a large ASD GWAS, highlighting polygenic heterogeneity and the value of large-scale GWAS in ASD.

Disentangling genetically confounded polygenic associations between Attention-Deficit/Hyperactivity Disorder, literacy and language

The paper investigates polygenic associations between ADHD and literacy/language abilities, finding that genetic confounding with educational attainment masks ADHD-specific reading impairments.

Genome-wide association study implicates CHRNA2 in cannabis use disorder

This paper identifies a genome-wide significant risk locus for cannabis use disorder, implicating CHRNA2 and linking it to cognitive performance.

Discovery Of The First Genome-Wide Significant Risk Loci For ADHD

Genome-wide association meta-analysis of 20,183 ADHD cases and 35,191 controls finds 12 significant loci; signal concentrates in conserved regions, constrained genes, and CNS regulatory elements.

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

This study identifies 114 genome-wide significant loci for schizophrenia and bipolar disorder, with specific subphenotype associations and four genes distinguishing the disorders.

Genome-wide Association Study of Anxiety and Stress-related Disorders in the iPSYCH Cohort

The paper conducts a genome-wide association study of anxiety and stress-related disorders in the iPSYCH cohort, identifying PDE4B as consistently associated with ASRD and showing genetic overlap with other traits.

Gene expression imputation across multiple brain regions reveals schizophrenia risk throughout development.

The paper uses transcriptomic imputation to identify schizophrenia risk genes across multiple brain regions, finding 71 associated genes and 36 enriched pathways.

The iPSYCH2012 case-cohort sample: New directions for unravelling genetic and environmental architectures of severe mental disorders

The paper introduces the iPSYCH2012 case-cohort sample, a large Danish population-based dataset for studying genetic and environmental factors in severe mental disorders.

Mitochondrial DNA SNPs associated with Schizophrenia exhibit Highly Variable Inter-allelic Haplogroup Affiliation and Nuclear Genogeographic Affinity: Bi-Genomic Linkage Disequilibrium raises Major Concerns for Link to Disease

The paper reanalyzes mtDNA SNPs associated with schizophrenia in Danish populations, finding significant bi-genomic linkage disequilibrium that may confound disease associations.

Complex spatio-temporal distribution and genogeographic affinity of mitochondrial DNA haplogroups in 24,216 Danes

The paper analyzes the spatio-temporal distribution and genogeographic affinity of mitochondrial DNA haplogroups in 24,216 Danes, finding increased frequencies of certain haplogroups linked to immigration.

Estimating the functional impact of INDELs in transcription factor binding sites: a genome-wide landscape

The paper introduces a bioinformatic method to predict the functional impact of INDELs in transcription factor binding sites, showing that deletions have the most severe effects while insertions are mostly neutral.