Michael Pilsl

The paper uses NMR and simulations to study dynamic motions in the eukaryotic RNA exosome complex, revealing conformational changes and a flexible plug region that blocks RNA pathways.

The paper identifies mutations in RNA polymerase I that enhance its activity, leading to increased rRNA production in yeast.

The paper investigates how the lobe-binding module of RNA polymerase I affects transcription fidelity, speed, and processivity in vitro, showing its unique ability to transcribe nucleosomal templates compared to Pol II.